Miami vs Louisville Prediction: Louisville Super Regional Preview
Last updated June 5, 2025

The 2025 NCAA Baseball Super Regionals present an intriguing showdown between the Miami Hurricanes and the Louisville Cardinals, commencing Friday, June 6. Both of these ACC teams have done a great job of navigating their respective paths to this stage, each bringing their own threats to Louisville. Here, we make our college baseball picks with our Miami vs Louisville prediction for the Super Regionals, as one of these conference rivals will punch their ticket to the College World Series in Omaha.
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Miami vs Louisville Super Regionals Preview
The Miami Hurricanes enter the Super Regionals with a 34–25 overall record and a 15–14 mark in ACC play. Under the guidance of head coach J.D. Arteaga, Miami clinched the Hattiesburg Regional title, splitting their final two games with hosts Southern Miss to advance. Miami benefited from Southern Miss' upset loss to Columbia in the first set of games, helping Miami to stay in the winner's bracket. The Hurricanes' roster features a blend of experience and youth, which they hope will lead them to celebrating on an opponent's field for the second weekend in a row.
On the other side, the Louisville Cardinals boast a 38–21 overall record, with a 15–15 conference performance. Led by veteran head coach Dan McDonnell in his 19th season, Louisville secured the Nashville Regional championship. The Cardinals upset hosts Vanderbilt in their second game of regional play, beating Wright State to go 3-0 and advance after the Raiders upset Vandy to prevent Louisville from having to play them again. Louisville did not expect to host a Super Regional going into last week, but they certainly earned the right to do so with their play in Nashville.
Despite playing in the same conference, this will be the first time that Miami and Louisville have faced off this year. The Cardinals have been strong at home, going 27-7 there this season, and they will aim to take advantage of that to move into the final eight teams still alive for the national title.
Betting Insights
As the Super Regionals approach, betting markets have provided insights into the perceived strengths of each team. According to recent odds, Louisville stands at -174 to advance to Omaha, while Miami is the underdog heading into the weekend at +134. Louisville is listed at +2500 to win the College World Series, while Miami stands at +3500. These figures suggest a slight edge for Louisville both this weekend and in the broader tournament context.
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Miami vs Louisville Super Regionals Prediction
After evaluating all available information, the Louisville Cardinals appear to hold a slight advantage entering the Super Regionals. Their home-field advantage, effective pitching, and consistent performance throughout the season position them favorably against the Hurricanes. My betting picks for this series lean towards Louisville securing the series victory.
Prediction: Louisville Cardinals win the series 2-1.
